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Alterations in VHL as potential biomarkers in renal-cell carcinoma

✍ Scribed by Gossage, Lucy; Eisen, Tim


Book ID
120159269
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
388 KB
Volume
7
Category
Article
ISSN
1759-4774

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✍ Cheryl Walker; Yong-Tae Ahn; Jeffrey Everitt; Xiaoqin Yuan πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 784 KB

Germline alterations of the human von Hippel-Lindau (VHL) tumor suppressor gene predispose t o renal cell carcinoma and a constellation of other tumor types found in VHL disease. This gene is also mutated or deleted in a high proportion of sporadic nonpapillary renal cell carcinomas. In the Eker rat