Alterations in spinal cord excitatory amino acid receptors in amyotrophic lateral sclerosis patients
β Scribed by H. Allaoua; I. Chaudieu; C. Krieger; P. Boksa; A. Privat; R. Quirion
- Book ID
- 115802904
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 881 KB
- Volume
- 579
- Category
- Article
- ISSN
- 0006-8993
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Recently, the excitatory amino acid neurotransmitter glutamate was implicated in the pathogenesis of a variety of chronic degenerative neurological diseases in humans and animals. This report describes abnormalities in excitatory amino acids in the central nervous system of 18 patients with amyotrop
## Abstract Transmitter receptor binding was estimated in the spinal cord of 6 subjects with amyotrophic lateral sclerosis (ALS) and 4 control subjects in assays using ^3^Hβquinuclidinyl benzilate for muscarinic cholinergic receptors, ^3^Hβstrychnine for glycinergic receptors, ^3^Hβspiroperidol for