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Excitatory amino acids in amyotrophic lateral sclerosis: An update

โœ Scribed by Jeffrey D. Rothstein; Ralph Kuncl; Vinay Chaudhry; Lora Clawson; David R Cornblath; Joseph T. Coyle; Daniel B. Drachman


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
223 KB
Volume
30
Category
Article
ISSN
0364-5134

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## Abstract The mechanism underlying selective motoneuronal loss in amyotrophic lateral sclerosis (ALS) remains uncertain. The pathogenesis appears to be a complex and multifactorial process. Glutamate excitotoxicity to motoneuron is one of the most intensely investigated targets for the treatment