Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis
โ Scribed by Sanne Piepers; Jan H. Veldink; Sonja W. De Jong; Ingeborg Van Der Tweel; W-Ludo Van Der Pol; Esther V. Uijtendaal; H. Jurgen Schelhaas; Hans Scheffer; Marianne De Visser; J. M. B. Vianney De Jong; John H. J. Wokke; Geert Jan Groeneveld; Leonard H. Van Den Berg
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 189 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0364-5134
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There is no satisfactory treatment for amyotrophic lateral sclerosis (ALS) [ 11. Ciliary neurotrophic factor (CNTF) is an endogenous protein that is released upon injury to the nervous system and limits the extent of injury-induced tieuronal damage in some nerve cells [2, 31. CNTF can be produced in
## Abstract The mechanism underlying selective motoneuronal loss in amyotrophic lateral sclerosis (ALS) remains uncertain. The pathogenesis appears to be a complex and multifactorial process. Glutamate excitotoxicity to motoneuron is one of the most intensely investigated targets for the treatment