๐”– Bobbio Scriptorium
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Reduced glycine receptor in the spinal cord in amyotrophic lateral sclerosis

โœ Scribed by Dr. Hideaki Hayashi; Masakazu Suga; Mei Satake; Tadao Tsubaki

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
285 KB
Volume
9
Category
Article
ISSN
0364-5134

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โœฆ Synopsis

Abstract

Transmitter receptor binding was estimated in the spinal cord of 6 subjects with amyotrophic lateral sclerosis (ALS) and 4 control subjects in assays using ^3^Hโ€quinuclidinyl benzilate for muscarinic cholinergic receptors, ^3^Hโ€strychnine for glycinergic receptors, ^3^Hโ€spiroperidol for dopaminergic receptors, ^3^Hโ€muscimol for GABAergic receptors, and ^3^Hโ€dihydroalprenolol for ฮฒโ€adrenergic receptors. In ALS, glycinergic receptor binding was greatly reduced in the anterior gray matter. This finding may be attributed to loss of large neurons in the anterior gray matter, known to be characteristic of ALS.

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