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Alterations in PC12 cells overexpressing the A4-C terminal region of the amyloid precursor protein


Book ID
123460490
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
120 KB
Volume
11
Category
Article
ISSN
0197-4580

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In the present study, we investigated effects of estrogen on cell death induced by carboxy-terminal fragment of amyloid precursor protein (CT), a candidate causative substance in the pathogenesis of Alzheimer's disease. 17 beta-Estradiol attenuated CT-induced cell death in PC12 cells, whereas 17 alp