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MEK inhibitors suppress β-amyloid production by altering the level of a β-C-terminal fragment of amyloid precursor protein in neuronal cells

✍ Scribed by Wataru Araki; Fuyuki Kametani; Akiko Oda; Akira Tamaoka


Book ID
113622102
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
546 KB
Volume
584
Category
Article
ISSN
0014-5793

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## Abstract The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), which is subsequently cleaved by γ‐secretase to produce Aβ. Our previous studies have shown that the proteas