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Self-oligomerization of NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer's disease amyloid, observed in the presence of a C-terminal Aβ fragment (residues 25–35)

✍ Scribed by Seung R Paik; Ju-Hyun Lee; Do-Hyung Kim; Chung-Soon Chang; Young-Sik Kim

Book ID: 117108610
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 133 KB
Volume: 421
Category: Article
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(97)01537-8

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## Abstract The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), which is subsequently cleaved by γ‐secretase to produce Aβ. Our previous studies have shown that the proteas