Alterations in Copy Number of c-erbB-2 and c-myc Proto-oncogenes in Advanced Stage of Human Breast Cancer
β Scribed by Hitoshi Tsuda; Setsuo Hirohashi; Teruyuki Hirota; Yukio Shimosato
- Book ID
- 115174855
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 507 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1320-5463
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Molecular probes for cellular proto-oncogenes have recently been extensively used in order to search for functional and structural alterations in tumor tissues. Variable, and sometimes contradictory, results have been obtained regarding the frequency and clinical significance of amplification of the
Amplification of the int-2 oncogene was measured in a series of breast tumours and related to amplification of the c-myc and c-erbB-2 oncogenes, histopathological features and relapse-free and overall survival. int-2 was amplified in I I%, c-myc in 20% and c-erbB-2 in 27% of the tumours assessed. in