Alteration orinhibition of topoisomerase II and gene amplification in cultured cells
โ Scribed by DILEONARDO, A; CAVOLINA, P; MADDALENA, A
- Book ID
- 122139010
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 132 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0309-1651
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Genomic stability was investigated in Chinese hamster ovary (CHO) and human hepatocellular carcinoma HepG2 cells selected for growth in the presence of cytotoxic concentrations of __N__โ(phosphonacetylโLโasparate) (PALA). In CHO cells selected with 9 ร LD~50~ PALA the carbamyl pโsynthet
Topoisomerase IIโฃ (TOP2A) is a key enzyme in DNA replication and a molecular target for many important anticancer drugs. TOP2A is amplified or deleted together with amplification of the closely located ERBB2/HER-2/neu oncogene in breast cancer. We characterized the copy number aberrations of TOP2A a
n sylvan la (K. B.T.) DNA was prepared from normal tissue and I9 lung cancer cell lines. Using probes which detect restriction fragment length polymorphisms at both the topoisomerase II u and p loci, heterozygosity was detected at a frequency of 0. I 7 and 0.37 for the