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Alteration of Pancreatic B-Cells in Wistar Rats Treated with Non-Diabetogenic Doses of Cyclosporin A

โœ Scribed by Hahn, H. J. ;Laube, R. ;Lucke, S. ;Besch, W.

Book ID
114801764
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
419 KB
Volume
70
Category
Article
ISSN
0901-9928

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Morphological and functional changes of
Morphological and functional changes of pancreatic B cells in cyclosporin A-treated rats
โœ U. Helmchen; W. E. Schmidt; E. G. Siegel; W. Creutzfeldt ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Springer ๐ŸŒ English โš– 695 KB

Cyclosporin A (50 mg/kg orally for 7 days) produced severe degranulation and hydropic degeneration of islet B cells in rats. These changes were accompanied by hyperglycaemia and hypoinsulinaemia, while the pancreatic insulin content decreased by 75%.