Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down’s syndrome
✍ Scribed by D. Pérez-Cremades; S. Hernández; J. M. Blasco-Ibáñez; C. Crespo; J. Nacher; E. Varea
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 590 KB
- Volume
- 117
- Category
- Article
- ISSN
- 1435-1463
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## Abstract Agonist‐ and guanine‐nucleotide‐stimulated phospholipase C‐β (PLC) activity was characterized in crude plasma membrane preparations from cerebral cortex, hippocampus and cerebellum of Ts65Dn mice, a model for Down syndrome, and their control littermates. The levels of expression of PLC‐
## Abstract Down syndrome (DS), the leading genetic cause of mental retardation, is characterized by reduced number of cortical neurons and brain size. The occurrence of these defects starting from early life stages points at altered developmental neurogenesis as their major determinant. The goal o