Alphaviruses are positive-stranded RNA viruses that have a broad host range and therefore are capable of replicating in many vertebrate and invertebrate cells. The single-stranded alphavirus genome is divided into two ORFs. The first ORF encodes the nonstructural proteins that are translated upon en
Alphavirus vectors for gene expression and vaccines
β Scribed by Sondra Schlesinger; Thomas W Dubensky Jr.
- Book ID
- 108476362
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 266 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0958-1669
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## Abstract The construction of layered DNAβRNA replicons has facilitated and expanded the use of alphavirus vectors to vaccine development, construction of packaging cell lines and longβterm heterologous gene expression. In these vector systems, the alphavirus replicon is under the control of a st