โ Scribed by Murty V.R. Chengalvala; Michael D. Lubeck; Bernard J. Selling; Robert J. Natuk; Kuo-Hom L. Hsu; Bruce B. Mason; Pranab K. Chanda; Ramesh A. Bhat; Bheem M. Bhat; Satoshi Mizutani; Alan R. Davis; Paul P. Hung
No coin nor oath required. For personal study only.
Adenoviruses possess a combination of features that make them highly suitable as vectors for expression of heterologous genes. Non-conditional and non-defective adeno-vectors have been constructed to obtain high level expression of a number of foreign genes and some of them have been shown in animal models to exhibit excellent promise as vaccine candidates.
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Improvements to vaccinia virus expression vectors continue to be made. In particular, there are new methods for the construction of recombinant viruses, ways of increasing the level of gene expression, and vectors that allow the inducible expression of selected genes.
## Abstract ## Background Adenovectors are widely used for efficient delivery of genes into a variety of cell types and organisms. However, the construction of the desired vector/genes combination, especially if it involves the cloning of several gene cassettes, can be laborious due to the large s