Alpha synuclein is present in Lewy bodies in sporadic Parkinson’s disease
✍ Scribed by Mezey, E; Dehejia, A M; Harta, G; Suchy, S F; Nussbaum, R L; Brownstein, M J; Polymeropoulos, M H
- Book ID
- 110058953
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 942 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1359-4184
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## Abstract The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median
alpha-Synuclein belongs to a small group of natively unfolded proteins that can transiently bind to lipid membranes and acquire a partial alpha-helical conformation. Its relevance to Parkinson's disease (PD) is based on mutations found in familial cases of the disease and its presence in filaments o