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Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson’s disease

✍ Scribed by P. M. Mattila; J. O. Rinne; H. Helenius; D. W. Dickson; M. Röyttä; P. M. Mattila


Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
71 KB
Volume
100
Category
Article
ISSN
0001-6322

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## Abstract Alpha‐synuclein gene (__SNCA__) mutations cause familial Parkinsonism but the role of __SNCA__ variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of __SNCA__ genetic variation in 452 idiopathic PD cases and 245 controls. __SNCA__ copy numb