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.alpha.-Aminoaldehydes: transition state analog inhibitors of leucine aminopeptidase

✍ Scribed by Andersson, Lars; Isley, Timothy C.; Wolfenden, Richard


Book ID
120595860
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
537 KB
Volume
21
Category
Article
ISSN
0006-2960

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Solid phase synthesis of phosphinopeptoi
✍ Peter H. Dorff; Gordon Chiu; Steven W. Goldstein; Bradley P. Morgan πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 192 KB

A procedure for preparing novel phosphinopeptolds, 1, on a solid support is described. The key step in the synthesis includes a conjugate addition of the trivalent form of a protected aminomethylphosphinic acid (5) to a resin-bound acrylate.