Allogeneic stem cell transplantation in patients with Fanconi's anemia and myelodysplasia or leukemia utilizing low-dose cyclophosphamide and total body irradiation
β Scribed by Ayas, M; Al-Jefri, A; Al-Mahr, M; Rifai, S; Moussa, E; Karaoui, M; Roberts, G; El-Solh, H
- Book ID
- 110014003
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 91 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0007-1188
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## Abstract To circumvent the cardiac toxicity of highβdose cyclophosphamide (CY) in the myeloablative conditioning for those with cardiac comorbidity, we developed a new cardiac sparing conditioning regimen (VP/rCY/TBI) composed of 12 Gy of total body irradiation (TBI), etoposide (VPβ16) (40 mg/kg
at the end ot treatmenΕ. We have noted also 38 patients (15%) ot 254 patients, with deacresing hemoglobin level during treatment higher than 1 gid!. Results: No impact on outcome ot treatment was observed in the group ot patients with low level ot Hgb betore irradiation. Inrease ot locoregional fai