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Safety and efficacy of total body irradiation, cyclophosphamide, and cytarabine as a conditioning regimen for allogeneic hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia

โœ Scribed by Takehiko Mori; Yoshinobu Aisa; Jun Kato; Akiko Yamane; Tomonori Nakazato; Naoyuki Shigematsu; Shinichiro Okamoto

Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
836 KB
Volume
87
Category
Article
ISSN
0361-8609

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A myeloablative conditioning regimen for
A myeloablative conditioning regimen for patients with impaired cardiac function undergoing allogeneic stem cell transplantation: Reduced cyclophosphamide combined with etoposide and total body irradiation
โœ Akihide Yoshimi; Yasuhito Nannya; Mamiko Sakata-Yanagimoto; Kumi Oshima; Tsuyosh ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 137 KB ๐Ÿ‘ 2 views

## Abstract To circumvent the cardiac toxicity of highโ€dose cyclophosphamide (CY) in the myeloablative conditioning for those with cardiac comorbidity, we developed a new cardiac sparing conditioning regimen (VP/rCY/TBI) composed of 12 Gy of total body irradiation (TBI), etoposide (VPโ€16) (40 mg/kg