Allelic loss on chromosomes 3p, 5q and 17p in renal cell carcinomas
β Scribed by Jun Suglrnura; Gen Tamura; Yasushi Suzuki; Tornoaki Fujioka
- Book ID
- 115175203
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 606 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1320-5463
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The aim of this investigation was to explore the relationships between pS3 mutation, DNA aneuploidy, 17p deletions, and clinical stage in ovarian cancer. Nuclear suspensions were obtained by tissue disaggregation, stained with propidium iodide, and analysed on a Coulter EPICS Elite flow cytometer. D
On a genetic level, renal-cell carcinoma has been characterized by an abnormality on the short arm of chromosome 3 (3p), which suggests the inactivation of a tumor suppressor gene. One tumor suppressor gene at 3p, the von Hippel-Lindau disease gene, is implicated in tumor development of a whole spec