Allelic loss on 17p13 (TP53) and allelic loss on 3p21 in early squamous cell carcinoma of the lung
β Scribed by Chiaki Endo; Masami Sato; Shigefumi Fujimura; Akira Sakurada; Hirokazu Aikawa; Satomi Takahashi; Katsuo Usuda; Yasuki Saito; Motoyasu Sagawa
- Book ID
- 113050260
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 184 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1436-2813
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The aim of this investigation was to explore the relationships between pS3 mutation, DNA aneuploidy, 17p deletions, and clinical stage in ovarian cancer. Nuclear suspensions were obtained by tissue disaggregation, stained with propidium iodide, and analysed on a Coulter EPICS Elite flow cytometer. D
## Background: An accumulation of mutations can result in carcinogenesis. comparing genetic alterations in preneoplastic lesions with those seen in cancer in the same patient may be helpful in the early diagnosis of lung carcinoma or preneoplastic lesions. ## Methods: To identify genetic alterati