𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Allelic imbalance and altered expression of genes in chromosome 2q11–2q16 from rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

✍ Scribed by Qiu, Cunping; Yu, Minshu; Shan, Liang; Snyderwine, Elizabeth G


Book ID
110067351
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
340 KB
Volume
22
Category
Article
ISSN
0950-9232

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Genomic imbalance in rat mammary gland c
✍ Minshu Yu; Doug-Young Ryu; Elizabeth G. Snyderwine 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB

2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a compound found in cooked meat, is a mammary gland carcinogen in female Sprague-Dawley rats. PhIP-induced rat mammary gland carcinomas were examined for mutations in several genes (exons) known to regulate cell growth and apoptosis, including

Reduced Brca1 protein expression in 2-am
✍ Eriko Okochi; Kazuaki Miyamoto; Kuniko Wakazono; Hiroshi Shima; Takashi Sugimura 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB

## Abstract Reduced expression of BRCA1 protein, caused by the hypermethylation of its gene promoter and by other mechanisms, is observed in most sporadic human breast cancers, whereas its somatic mutations are rare. In the present study, we demonstrate that immunoreactivity of __Brca1__ was reduce

Infrequent mutation of ha-ras and p53 in
✍ Toshikazu Ushijima; Hideki Kakiuchi; Hiroshi Makino; Ryohei Hasegawa; Yukihito I 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 586 KB

## Abstract 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine(PhlP) is the most abundant of the heterocyclic amines, a group of potent carcinogens contained in cooked meat and fish. Female F344 rats fed a diet containing 100 or 400 ppm PhIP developed mammary carcinomas within 104 or 52 wk, respec

Microsatellite instability and loss of h
✍ Minoru Toyota; Toshikazu Ushijima; John H. Weisburger; Yoko Hosoya; Federico Can 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 596 KB

## Microsatellite instability (MI) and loss of heterozygosity (LOH) were examined in mammary tumors induced in Sprague-Dawley x F344 F1 female rats by 2-amino-l-methyl-6-phenylimidazo[4,5-blpyridine (PhlP). Examination of 62 microsatellite loci revealed M I in nine of 15 (60%) PhlP-induced mammary