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Frequent c-Ha-ras gene mutations in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

✍ Scribed by Naomi Hokaiwado; Makoto Asamoto; Young-Man Cho; Katsumi Imaida; Tomoyuki Shirai

Book ID
117466782
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
100 KB
Volume
163
Category
Article
ISSN
0304-3835

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Activating mutations in and expression of the Ha-ras gene were examined in benign and malignant female Sprague-Dawley rat mammary gland tumors induced by the heterocyclic amine 2-amino-1-methyl-6phenylimidazo[4,5-b]pyridine (PhIP) and promoted by a diet high in polyunsaturated fat. Ha-ras mutations