Allelic expression of the NF2 gene in neurofibromatosis 2 and schwannomatosis
β Scribed by L. B. Jacoby; Mia MacCollin; Dilys M. Parry; Lan Kluwe; Julie Lynch; Deborah Jones; James F. Gusella
- Book ID
- 106257451
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 123 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1364-6745
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Schwannomatosis is characterized by multiple peripheral and cranial nerve schwannomas that occur in the absence of bilateral 8th cranial nerve schwannomas. The latter is the main diagnostic criterion of neurofibromatosis type 2 (NF2), which is a related but distinct disorder. The genetic factors und
## Abstract Measuring correlation in clinical traits among relatives is important to our understanding of the causes of variable expressivity in Mendelian diseases. Random effects models are widely used to estimate intrafamilial correlations, but such models have limitations. We incorporated surviv