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Allele-specific regulation of primary cilia function by the von Hippel–Lindau tumor suppressor

✍ Scribed by Lolkema, Martijn P; Mans, Dorus A; Ulfman, Laurien H; Volpi, Stefano; Voest, Emile E; Giles, Rachel H


Book ID
110027230
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
287 KB
Volume
16
Category
Article
ISSN
1018-4813

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## Abstract Hypoxia–inducible factor (HIF) remains the central focus of oxygen sensing during hypoxia. HIF is a heterodimeric transcription factor consisting of an oxygen‐regulated alpha‐ and a constitutively expressed beta subunit. The von Hippel‐Lindau tumor suppressor (pVHL) is a component of th