## Abstract We previously identified 9 genes (i.e., thymosin β4, secreted protein acidic and rich in cysteine, Cap43, ceruloplasmin, serum amyloid A, heat shock protein 90, LOT1, osteopontin and casein kinase Iγ) that are more highly expressed in cancerous regions than in noncancerous regions in hu
✦ LIBER ✦
Cancer cells promote survival through depletion of the von Hippel–Lindau tumor suppressor by protein crosslinking
✍ Scribed by Jeon, Y; Kim, D-H; Ahn, E-R; Shin, J-E; Lee, B I; Lee, H; Kim, D-S; Choi, Y-B; Han, B-G; Park, S-Y
- Book ID
- 109972859
- Publisher
- Nature Publishing Group
- Year
- 2011
- Tongue
- English
- Weight
- 833 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0950-9232
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Germline mutations in the von Hippel-Lindau (VHL) disease tumor suppressor gene (TSG) convey a high risk of clear-cell renal-cell carcinoma (CC-RCC) and most sporadic CC-RCCs demonstrate somatic inactivation of the VHL TSG. However, the existence of further CC-RCC gatekeeper genes is implied by CC-R