Little is known about the biology of Merkel cell carcinoma (MCC), also called small cell carcinoma of the skin. MCC has similarities with small cell lung cancer (SCLC): both are neuroendocrine malignancies with early metastasis t o distant sites and a poor prognosis. Small cell lung cancer biopsies
Allele Deletion Mapping of the Short Arm of Human Chromosome 3 in Renal Carcinoma
โ Scribed by I. V. Bazov; T. P. Kazubskaya; V. D. Ermilova; R. F. Gar'kavtseva; V. I. Loginov; E. R. Zabarovsky; E. A. Braga
- Book ID
- 110291205
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 2001
- Tongue
- English
- Weight
- 107 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0026-8933
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Previous cytogenetic investigations have revealed frequent deletions and ocher unbalanced structural rearrangements of 3p in human malignant mesothelioma, We have performed a restriction fragment length polymorphism analysis by using the polymerase chain reaction and primer sets for seven DNA marker
We used I0 restriction fragment length polymorphism (RFLP) probes spanning the length of the short arm of chromosome 3 (3p) t o map deletion sites in human lung cancer. Two approaches were used. I) When a patient's tumor and normal tissue were available, loci with allelic heterozygosity in the norma
Frequent losses of heterozygosity observed at several chromosomal loci in primary lung cancers have indicated the existence of several tumor suppressor genes associated with this type of cancer. We have examined loss of heterozygosity on chromosomal arm 8p in 49 cases of non-small cell lung carcinom