A novel α-alkylation of α,β-epoxy ketone
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E.J. Corey; Lawrence S. Melvin Jr.; Martin F. Haslanger
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Article
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1975
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Elsevier Science
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French
⚖ 209 KB
In connection with studies on the total synthesis of the aglycone of erythromycin B, erythronolide B (II), it was of interest to devise a method for the conversion of the cu,@-unsaturated ketone I to II. The ketone I is an especially attractive synthetic intermediate for several reasons including ac