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Alkylative elimination of α,β-epoxy tosylhydrazones

✍ Scribed by S. Chandrasekhar; Mohamed Takhi; J.S. Yadav


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
130 KB
Volume
36
Category
Article
ISSN
0040-4039

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A novel α-alkylation of α,β-epoxy ketone
✍ E.J. Corey; Lawrence S. Melvin Jr.; Martin F. Haslanger 📂 Article 📅 1975 🏛 Elsevier Science 🌐 French ⚖ 209 KB

In connection with studies on the total synthesis of the aglycone of erythromycin B, erythronolide B (II), it was of interest to devise a method for the conversion of the cu,@-unsaturated ketone I to II. The ketone I is an especially attractive synthetic intermediate for several reasons including ac