Recent insights (1) in the remarkable solvent properties of dimethyl eulfoxida (DMSO), and our own interest in the chemistry of isopropcnyl ethers (2) led u8 to consider the poraibility of direot 0-alkylation of ethyl aoetoaoetate in that solvent. The connection i# that Kornblum'rr work (3) suggests
Alkylation of ketones by use of solid KOH in dimethyl sulfoxide
โ Scribed by Elke Langhals; Heinz Langhals
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 201 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
N-Substituted amides have been prepared by aminolysiB of esters using the magnesium halide,' eodiumae3 and lithium3 salts of primary amines. Sodium methoxide4 and bifunctional catalysts (such as 2-pyridone)5 have aleo been employed in the aminolyeis of esters by primary amine8 but yield8 are not uni
l,l,l',l'-tetroxide (3). These products can be isolated from the dark brown reaction mixture by fractional crystallization from benzene or by column chromatography on alumina with acetone as eluting agent. The absence of an amino-olefinic grouping in (2) and (3) follows from their stability towards