Alkylation of 4-picolinium salts under phase transfer conditions
✍ Scribed by R. V. Butkene; G. V. Mikul'skene; O. S. éikher-Lorka; G. -K. K. Kupyatis
- Book ID
- 104783271
- Publisher
- Springer US
- Year
- 1989
- Tongue
- English
- Weight
- 412 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0009-3122
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The reduction of alkyl 2,4+lkadienoates, bearing alkyl substituents on the diene system, with sodium dithionite, under phase transfer conditions, gives satisfactory yields of E:i! isomeric mixtures of the corresponding 3\_alkenoetes, except in the case Gf-the C-2 substituted substrate which afforded
The catalytic asymmetric alkylation reaction of 0t-fluorotetralones promoted by a chiral quaternary ammonium salt derived from cinchonine under phase-transfer catalyzed conditions was described. The reaction proceeded smoothly to give the desired products with up to 91% ee. This methodology provides