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Asymmetric alkylation reaction of α-fluorotetralone under phase-transfer catalyzed conditions

✍ Scribed by Shigeru Arai; Makoto Oku; Toshimasa Ishida; Takayuki Shioiri

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
267 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The catalytic asymmetric alkylation reaction of 0t-fluorotetralones promoted by a chiral quaternary ammonium salt derived from cinchonine under phase-transfer catalyzed conditions was described. The reaction proceeded smoothly to give the desired products with up to 91% ee. This methodology provides a practical protocol for the preparation of optically active fluoro compounds on a large scale.

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