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Asymmetric cyclopropanation reaction Under phase-transfer catalyzed conditions

✍ Scribed by Shigeru Arai; Keiji Nakayama; Toshimasa Ishida; Takayuki Shioiri

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 242 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00679-6

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✦ Synopsis

An asymmetric cyclopropanation reaction was developed using chiral quaternary ammonium salts as the phase-transfer catalyst (PTC). The reaction smoothly proceeded to give the desired bicyclic compounds with complete stereocontrol in the presence of a catalytic amount of chiral quaternary salts as the PTC, which are derived from readily available chiral amines, with up to 83% ee under mild reaction conditions.

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