𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Alkylation and arylation of pyrazoles under solvent-free conditions: Conventional heating versus microwave irradiation

✍ Scribed by Inés Almena; Enrique Díz-Barra; Antonio De La Hoz; Juliana Ruiz; Ana Sínchez-Migallón; José Elguero

Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
408 KB
Volume
35
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The use of sodium hydrogen carbonate under solvent‐free conditions and microwave irradiation is by far the best method for __N‐__alkylating pyrazoles. The yields are good and the method is devoid of side reactions (quaternization, isomerization, hydrogen halide elimination). Solvent‐free conditions are the only ones that allow us to prepare 1‐substituted pyrazoles from secondary halides. The procedure using quaternary salts in one‐pot provides an interesting alternative for the preparation of 1‐heteroarylpyrazoles.

📜 SIMILAR VOLUMES

Quaternization and dequaternization of p
Quaternization and dequaternization of pyrazoles in solvent-free conditions: Conventional heating versus microwave irradiation
✍ Enrique Díez-Barra; Antonio De La Hoz; Ana Sánchez-Migallón; José Elguero 📂 Article 📅 1999 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 363 KB

## Abstract We report a study on the quaternization and dequaternization of pyrazoles by conventional heating and microwave irradiation in solvent‐free conditions. Microwave irradiation produces an acceleration in the quaternization rate and a rapid equilibration between quaternized and non quatern

ChemInform Abstract: Quaternization and
ChemInform Abstract: Quaternization and Dequaternization of Pyrazoles in Solvent-Free Conditions: Conventional Heating versus Microwave Irradiation.
✍ Enrique Diez-Barra; Antonio de la Hoz; Ana Sanchez-Migallon; Jose Elguero 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v