Mechanism of action of the aqueous seed
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M. O. Uguru; J. C. Aguiyi; A. A. Gesa
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Article
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1997
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John Wiley and Sons
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English
β 75 KB
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The hot water extract (HWE) of the seed of Mucuna pruriens dose-dependently contracted the guinea-pig ileum. The ED 50 and pD 2 values for the HWE was lower than those of ACh and histamine. Cyproheptadine and promethazine (10 ng/mL) significantly antagonized the effects of histamine, 5-hydroxytrypta