Cephradine yields an unique alkaline degradation product, which has been identified by proton magnetic resonance, IT-NMR, and mass spectrometry as 2-[6-(1,4-cyclohexadine-lyl) -2.5dioxo -3piperazinyl] -5,6-dihydro -5methyl -2H-1,3thiazine-4carboxylic acid, sodium salt. Keyphrases 0 Cephradine-struct
Alkaline degradation products of concanamycin a
β Scribed by Haruyasu Kinashi; Kinumi Someno; Kenjl Sakaguchi; Tsutomu Higashijima; Tatsuo Miyazawa
- Book ID
- 104242518
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 189 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The structures of alkaline degradation products of concanamycin A were elucidated by analysis of their 270 MHz PMR spectra. Concanamycins A, B, and C, produced by Streptomyces diastatochromogenes S45, inhibit the proliferation of the mouse splenic lymphocytes stimulated by concanavalin A.
π SIMILAR VOLUMES
The structure of concanamycin A was proposed on the basis of PMR analyses of concanamycin A and its ozonolysis products. In the preceding paper, concanamycin A (1) was subjected to alkaline degradation to afford the anhydroaglycone Pl and the sugar Sl, and their structures were described. 1 In ord
The degradation of fructose with aqueous Ca(OH) 2 gives products similar to the same reaction with glucose. The fructofuranosyl linkage in glycosides cleaves at 130-140Β°C and the fructose so released degrades to products that are different in proportion to those from free fructose under similar reac