✦ LIBER ✦

Alcohol and oxidative liver injury

✍ Scribed by Aparajita Dey; Arthur I. Cederbaum

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 562 KB
Volume: 43
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.20957

No coin nor oath required. For personal study only.

✦ Synopsis

Acute and chronic ethanol treatment has been shown to increase the production of reactive oxygen species, lower cellular antioxidant levels, and enhance oxidative stress in many tissues, especially the liver. Ethanol-induced oxidative stress plays a major role in the mechanisms by which ethanol produces liver injury. Many pathways play a key role in how ethanol induces oxidative stress. This review summarizes some of the leading pathways and discusses the evidence for their contribution to alcohol-induced liver injury. Many of the seminal reports in this topic have been published in Hepatology, and it is fitting to review this research area for the 25th Anniversary Issue of the Journal. (Hepatology 2006;43: S63-S74.)

📜 SIMILAR VOLUMES

Nitric oxide in liver injury

✍ Mark G. Clemens 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 50 KB

IgA deposition and synthesis in alcoholi

IgA deposition and synthesis in alcoholic liver injury

✍ D. R. Triger 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 150 KB

Immunoglobulin deposition in alcoholic and nonalcoholic liver disease was studied using an indirect immunoperoxidase technique. A continuous pattern of IgA deposition, with IgA outlining the sinusoids, was shown to be a specific and sensitive marker for liver disease caused by alcohol in both cirrho

Hepatitis B and C virus and alcohol-indu

Hepatitis B and C virus and alcohol-induced liver injury

✍ Jack R. Wands; Hubert E. Blum 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 457 KB 👁 1 views

Keratin mutation primes mouse liver to o

Keratin mutation primes mouse liver to oxidative injury

✍ Qin Zhou; Xuhuai Ji; Lixin Chen; Harry B. Greenberg; Shelly C. Lu; M. Bishr Omar 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 301 KB

Mutation of the cytoskeletal intermediate filament proteins keratin 8 and keratin 18 (K8/K18) is associated with cirrhosis in humans, whereas transgenic mice that overexpress K18 Arg89-->Cys (R89C) have significant predisposition to liver injury. To study the mechanism of keratin-associated predispo

Inactivation of Kupffer cells prevents e

Inactivation of Kupffer cells prevents early alcohol-induced liver injury

✍ Yukito Adachi; Blair U. Bradford; Wenshi Gao; Heidi K. Bojes; Ronald G. Thurman 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 809 KB

It is well recognized that consumption of alcohol leads to liver disease in a dose-dependent manner; however, the exact mechanisms remain unclear. Hypoxia subsequent to a hypermetabolic state may be involved: therefore, when it was observed recently that inactivation of Kupffer cells prevented stimu

Alcoholic liver injury: Defenestration i

Alcoholic liver injury: Defenestration in noncirrhotic livers—a scanning electron microscopic study

✍ Thomas Horn; Per Christoffersen; Jens H. Henriksen 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 658 KB