✦ LIBER ✦

IgA deposition and synthesis in alcoholic liver injury

✍ Scribed by D. R. Triger

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 150 KB
Volume: 8
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840080142

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✦ Synopsis

Immunoglobulin deposition in alcoholic and nonalcoholic liver disease was studied using an indirect immunoperoxidase technique. A continuous pattern of IgA deposition, with IgA outlining the sinusoids, was shown to be a specific and sensitive marker for liver disease caused by alcohol in both cirrhotic and non-cirrhotic livers. The sensitivity was lowest in cases of alcoholic disease showing fatty change alone. In one case it was possible to show the absence of IgA in liver disease caused by a drug, which was histologically indistinguishable from alcoholic hepatitis.

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