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Albumin induces upregulation of matrix metalloproteinase-9 in astrocytes via MAPK and reactive oxygen species-dependent pathways

✍ Scribed by Hantamalala Ralay Ranaivo, Jessica N Hodge, Nicole Choi, Mark S Wainwright

Book ID: 119907547
Publisher: BioMed Central
Year: 2012
Tongue: English
Weight: 812 KB
Volume: 9
Category: Article
ISSN: 1742-2094
DOI: 10.1186/1742-2094-9-68

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## Abstract Upregulation of matrix metalloproteinases (MMPs), especially MMP‐9, by oxidized low‐density lipoprotein (oxLDL) is implicated in many inflammatory diseases including brain injury. However, the signaling mechanisms underlying oxLDL‐induced MMP‐9 expression in astrocytes largely remain un