High Glucose Induces Reactive Oxygen Species-Dependent Matrix Metalloproteinase-9 Expression and Cell Migration in Brain Astrocytes
β Scribed by Hsieh, Hsi-Lung; Lin, Chih-Chung; Hsiao, Li-Der; Yang, Chuen-Mao
- Book ID
- 120159078
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 836 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0893-7648
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## Abstract Many reports have shown that matrix metalloproteinase (MMP)β9 plays an important role in brain inflammation and diseases. In our previous study, bradykinin (BK) has been shown to induce proMMPβ9 expression via MAPKs and NFβΞΊB in rat brain astrocytes (RBAβ1). However, the molecular mecha
## Abstract Upregulation of matrix metalloproteinases (MMPs), especially MMPβ9, by oxidized lowβdensity lipoprotein (oxLDL) is implicated in many inflammatory diseases including brain injury. However, the signaling mechanisms underlying oxLDLβinduced MMPβ9 expression in astrocytes largely remain un