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Japanese encephalitis virus induces matrix metalloproteinase-9 expression via a ROS/c-Src/PDGFR/PI3K/Akt/MAPKs-dependent AP-1 pathway in rat brain astrocytes

✍ Scribed by Chuen-Mao Yang; Chih-Chung Lin; I-Ta Lee; Yi-Hsin Lin; Caleb M Yang; Wei-June Chen; Mei-Jie Jou; Li-Der Hsiao

Book ID: 115022144
Publisher: BioMed Central
Year: 2012
Tongue: English
Weight: 1004 KB
Volume: 9
Category: Article
ISSN: 1742-2094
DOI: 10.1186/1742-2094-9-12

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## Abstract Enterovirus 71 (EV71) induces the expression of cyclooxgenase (COX)‐2 served as a major neurotoxic factor in CNS injury. However, the mechanisms underlying EV71‐initiated intracellular signaling pathways leading to COX‐2 expression remain unknown. Therefore, we investigated the mechanis