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AID in somatic hypermutation and class switch recombination

✍ Scribed by Simonne Longerich; Uttiya Basu; Frederick Alt; Ursula Storb


Book ID
108099520
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
324 KB
Volume
18
Category
Article
ISSN
0952-7915

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## Abstract Secondary diversification of immunoglobulin (Ig) genes occurs through somatic hypermutation (SHM) in B cells of the germinal center (GC). The GC reaction is associated with a high frequency ofDNA double‐strand breaks (DSB) in the hypermutation domain of Ig genes. Homologous recombinatio

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