AID in somatic hypermutation and class switch recombination
β Scribed by Simonne Longerich; Uttiya Basu; Frederick Alt; Ursula Storb
- Book ID
- 108099520
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 324 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0952-7915
No coin nor oath required. For personal study only.
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## Abstract Secondary diversification of immunoglobulin (Ig) genes occurs through somatic hypermutation (SHM) in B cells of the germinal center (GC). The GC reaction is associated with a high frequency ofDNA doubleβstrand breaks (DSB) in the hypermutation domain of Ig genes. Homologous recombinatio
## Abstract Immunoglobulin class switch recombination (CSR) is initiated by activationβinduced cytidine deaminase (AID), an enzyme that deaminates cytidine residues in singleβstranded DNA. U:G mismatches created by AID are processed to produce lesions that recruit and activate DNA damage response p
## Abstract __Runt__βrelated (__Runx__) transcriptional regulators play essential roles in various cell fate determination processes, and dysfunction of these regulators causes many human diseases. Considerable insight into the functions of Runx proteins was provided mainly by studies of hematopoie