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Functions of Runx in IgA class switch recombination

✍ Scribed by Dr. Manabu Sugai; Kakeru Watanabe; Yukiko Nambu; Tatsunari Hayashi; Akira Shimizu

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
280 KB
Volume
112
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Runt‐related (Runx) transcriptional regulators play essential roles in various cell fate determination processes, and dysfunction of these regulators causes many human diseases. Considerable insight into the functions of Runx proteins was provided mainly by studies of hematopoietic and skeletal disorders. Recently, extensive investigations have revealed new functions of these transcription factors in immune cell differentiation and functioning. In the present review, we discuss the mechanisms of selective IgA production in the intestine and report the involvement of Runx proteins in this process. J. Cell. Biochem. 112: 409–414, 2011. © 2010 Wiley‐Liss, Inc.

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