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Aggregation and Water-Membrane Partition as Major Determinants of the Activity of the Antibiotic Peptide Trichogin GA IV

✍ Scribed by Stella, Lorenzo; Mazzuca, Claudia; Venanzi, Mariano; Palleschi, Antonio; Didonè, Mara; Formaggio, Fernando; Toniolo, Claudio; Pispisa, Basilio


Book ID
118515966
Publisher
Biophysical Society
Year
2004
Tongue
English
Weight
168 KB
Volume
86
Category
Article
ISSN
0006-3495

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✍ Elsa Locardi; Stefano Mammi; Evaristo Peggion; Vania Monaco; Fernando Formaggio; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB 👁 2 views

We have synthesized by solution-phase methods two analogues of the 11-residue lipopeptaibol antibiotic trichogin GA IV in which the N-terminal n-octanoyl group is replaced either by an N-acetylated 2-amino-2-methyl-L-undecanoic acid or by an N-acetylated h-aminoisobutyric acid. CD, FTIR absorption,