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Mechanism of Membrane Activity of the Antibiotic Trichogin GA IV: A Two-State Transition Controlled by Peptide Concentration

✍ Scribed by Mazzuca, Claudia; Stella, Lorenzo; Venanzi, Mariano; Formaggio, Fernando; Toniolo, Claudio; Pispisa, Basilio


Book ID
119919246
Publisher
Biophysical Society
Year
2005
Tongue
English
Weight
199 KB
Volume
88
Category
Article
ISSN
0006-3495

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We have synthesized by solution-phase methods two analogues of the 11-residue lipopeptaibol antibiotic trichogin GA IV in which the N-terminal n-octanoyl group is replaced either by an N-acetylated 2-amino-2-methyl-L-undecanoic acid or by an N-acetylated h-aminoisobutyric acid. CD, FTIR absorption,