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Age-related alterations in cell division and cell cycle kinetics in control and trimethyltin-treated lymphocytes of human individuals

โœ Scribed by Bani Bandana Ganguly

Publisher
Springer Netherlands
Year
1995
Tongue
English
Weight
381 KB
Volume
8
Category
Article
ISSN
1572-8773

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โœฆ Synopsis

Trimethyltin chloride induced age-related suppression of cell division and cell cycle kinetics in human peripheral blood lymphoeytes cultured in RPMI 1640 culture medium supplemented with human AB serum, phytohemagglutinin and bromodeoxyuridine. A high frequency of Mt (first metaphase) cells was seen in cultures treated with a high dose (G = i.0/~g per culture) and in lymphocytes from donors in the age range 40-70 years. The delay in cell division and cell cycle kinetics may indicate a longer duration in DNA synthesis induced by trimethyltin chloride in aged lymphocytes.

๐Ÿ“œ SIMILAR VOLUMES

DNA synthesis and proliferation of human
DNA synthesis and proliferation of human lymphocytes in vitro: III. Fate of cycling cells in aging cultures of phytohemagglutinin stimulated human lymphocytes
โœ John Mendelsohn; Dorothy Hudig; Janice Castagnola ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 813 KB

There are few data available on cell cycle events that occur when proliferation of normal cells in culture is curtailed due to "natural aging" of the culture conditions. Stathmokinetic and cytofluorometry studies were performed on PHA-stimulated human lymphocyte cultures for eight consecutive days.