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Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain

✍ Scribed by Hatem Sallam; Patricia Jimenez; Hairong Song; Marina Vita; Angel Cedazo-Minguez; Moustapha Hassan

Book ID: 119346542
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 439 KB
Volume: 58
Category: Article
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2008.05.010

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## Abstract Neurotrophins play essential roles in the development, differentiation, and survival of neuronal and nonneuronal cells. Alterations in neurotrophin expression have been implicated in a variety of neurodegenerative disorders. Dysregulation of brain‐derived neurotrophic factor (BDNF) has