We have investigated the expression of Cdk5 and its regulatory subunit, p35, in the developing rat lens from embryonic day 16 (E16) to postnatal day 8 (P8). Reverse transcription and polymerase chain reaction (RT/PCR) detected Cdk5 and p35 mRNA expression in lens epithelial cells and in differentiat
The Expression of Cdk5, p35, p39, and Cdk5 Kinase Activity in Developing, Adult, and Aged Rat Brains
β Scribed by Dong-Cheng Wu; Ya-Ping Yu; Nelson T. K. Lee; Albert C. H. Yu; Jerry H. C. Wang; Yi-Fan Han
- Book ID
- 110251352
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 81 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0364-3190
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## Abstract Although protein kinase Cdk5βp35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its
## Abstract Cyclinβdependent kinase 5 (Cdk5) is a unique member of the Cdk family; its kinase activity requires association with its activator, p35 or p39. p35 is the strongest and best characterized activator. Previous studies showed that p35 is a neuronβspecific protein that restricts Cdk5 activi