Age-dependent effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): Correlation with monoamine oxidase-B
โ Scribed by Sharon L. Walsh; Dr. George C. Wagner
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 861 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0887-4476
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Primary cultures of mouse astrocytes were treated with both the monoamine oxidase (MAO) A inhibitor, clorgyline, and the MA0 B inhibitor, deprenyl, prior to the addition of the neurotoxicant 1 -methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). Production of the 1-methyl-4-phenylpyridinium (MPP+) to
## Abstract Monoamine oxidase B metabolizes 1โmethylโ4โphenylโ1,2,3,6โtetrahydropyridine (MPTP; **1**) first to 1โmethylโ4โphenylโ2,3โdihydropyridinium salt (MPDP^+^; **5**), and then to 1โmethylโ4โphenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5โmethyl analog **6** wa