Neurochemical Evidence for Agmatine Modulation of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Neurotoxicity
β Scribed by Gad M. Gilad; Varda H. Gilad; John P. M. Finberg; Jose M. Rabey
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 318 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0364-3190
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## Abstract In 1βmethylβ4βphenylβ1,2,3,6βtetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1βmethylβ4βphenylpyridinium (MPP
Primary cultures of mouse astrocytes were treated with both the monoamine oxidase (MAO) A inhibitor, clorgyline, and the MA0 B inhibitor, deprenyl, prior to the addition of the neurotoxicant 1 -methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). Production of the 1-methyl-4-phenylpyridinium (MPP+) to