Oxidation of 1-amino-4-phenyl-1,2,3,6-tetrahydropyridine, a 1-amino analog of MPTP, by type A and B monoamine oxidase
โ Scribed by M. Umeda; S. Aoyama; T. Kaiya; K. Kohda; W. Maruyama; M. Naoi
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 231 KB
- Volume
- 105
- Category
- Article
- ISSN
- 1435-1463
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๐ SIMILAR VOLUMES
## Abstract Monoamine oxidase B metabolizes 1โmethylโ4โphenylโ1,2,3,6โtetrahydropyridine (MPTP; **1**) first to 1โmethylโ4โphenylโ2,3โdihydropyridinium salt (MPDP^+^; **5**), and then to 1โmethylโ4โphenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5โmethyl analog **6** wa
Primary cultures of mouse astrocytes were treated with both the monoamine oxidase (MAO) A inhibitor, clorgyline, and the MA0 B inhibitor, deprenyl, prior to the addition of the neurotoxicant 1 -methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). Production of the 1-methyl-4-phenylpyridinium (MPP+) to